Hi. Who else here with Type 1 diabetes has other autoimmune diseases that are common in Type 1's?

I also have Hashimoto's Thyroiditis (Dx age 10), and Celiac Disease (Dx age 22).

The rate of Celiac occurring alongside Type 1 diabetes is 2-13% depending on the study. It is extremely under diagnosed, so it may be much higher.

(Celiac Disease is NOT linked to Type 2 diabetes, the common kind, since Type 2 diabetes is caused by insulin resistance and NOT autoimmunity.)

Yes, the gluten free diet IS hard! But I survive....

It is never known if undxd or ntreated diabetes is the causation or relut in other diseases. Such as the conundrum of lupus. It is not confimed if one caused theother, in any case it is a mobius loop.
Mucosial colitis was caused and becuas eof dietf or it aggrivated diabetes,] OD is a genetic mutation and it is belived that because diabetes s so prevalent inmy family the two go hand in hand.

What I do know is thebetter in control withmultiple shots during the day the less I feel the effects of the other conditions.

I am not quite sure what you mean? Are you saying you have Lupus, as well as MODY? MODY is a genetic defect and not autoimmune, so the two are not linked. It is possible to have both MODY and autoimmune diabetes/conditions in your family as well. I have to point out though that MODY is NOT linked to autoimmune diseases, unfortunately it just looks like your family won the "bad gene pool lottery", and you have genetic disposition for both. Colitis IS an autoimmune disease.

One autoimmune disease doesn't "cause" another, but there is a shared defect in the body's ability to regulate rogue autoimmune T-cells. There is a genetic disposition shared among all autoimmune disease. Another idea is the "leaky gut" theory, in which people with autoimmune diseases let in whole foreign proteins, which then trigger the autoimmune response. Different triggers may manifest as different diseases by the same mechanism.

There is no reason or evidence to suggest that treating one disease can prevent others from occurring. They often cluster together.

The exception to this is Celiac, although it is not conclusive. There is some evidence to suggest a gluten and casein free diet is beneficial to delay or *possibly* prevent other autoimmunities in those with Celiac, but not all studies support this.

P.S. I was diagnosed with Type 1 at age 2.

Do you even know what MODY is???????????????
Mucosial colitis is not an autoimmune disease..
Lupus has variations........

MODY is NOT autoimmune, which is why I was confused that you were linking it to autoimmune diseases like Type 1 diabetes and Lupus.

What is MODY?
Maturity Onset Diabetes of the Young (MODY) is a group of diabetes disorders that affects about 2% of people with diabetes. MODY is often not recognised and people may be treated as Type 1 or Type 2 diabetes by their doctors. MODY has four main characteristics:

Diabetes presents at a young age, usually less than 25 years of age.
MODY runs in families through several generations. A parent with MODY has a 50% chance of passing on MODY to their child. This is called autosomal dominant inheritance.
People with MODY do not always need insulin treatment and can often be treated with diabetes pills or meal planning alone.
People with MODY do not produce enough insulin; this is different to Type 2 diabetes where people frequently produce lots of insulin but don’t respond to their insulin.
Why is MODY important?
MODY was first described by Tattersall (U.K.) (1, 2) and Fajan (U.S.A.) (2) in 1974, after they had noticed a group of young people with diabetes who were treated without insulin 2 years or more after diagnosis. Since the 1970s there has been great interest in MODY as it is a genetic form of diabetes. Each type of MODY is caused by a single gene not working correctly whereas Type 2 diabetes seems to be caused by minor problems in several genes at once. By studying MODY genes (3, 4), scientists can get insights into the mechanisms causing all types of diabetes and potential treatments for diabetes.

The first MODY gene was found in 1992 (5), and there are now six known genes in which defects will cause MODY (4). These genes are for the body’s glucose sensor (glucokinase), and five transcription factors that control the way insulin is produced from the beta cells of the pancreas (HNF-1 alpha, HNF-1 beta, HNF-4alpha, IPF-1, and NEURO-D1). These six genes each produce slightly different forms of diabetes (4, 6).

MODY mutations have been found in many different ethnic groups, with glucokinase and HNF-1 alpha being the commonest types by far. In total MODY makes up between 2-5% of patients with Non-Type 1 diabetes. 15% of MODY patients will not have a known MODY mutation; these people are said to have MODY X, and work is continuing to find the gene disorders responsible (3, 4).

Varieties of MODY
MODY 1 (HNF-4?) Rare form of MODY. Similar effects to MODY 3.


MODY 2 (Glucokinase) Causes between 10-65% of MODY. Causes mild diabetes that rarely causes complications. Can often be treated with meal planning alone. Often diagnosed in childhood or pregnancy.


MODY 3 (HNF-1 alpha) Causes between 20-75% of MODY. Causes progressive diabetes and patients may get diabetes complications. Usually diagnosed after puberty. Sensitive to sulfonylurea drugs.


MODY 4 (IPF-1) Rare form of MODY. Seems to produce relatively mild diabetes.


MODY 5 (HNF-1 beta) Rare form of MODY. Associated with kidney disease that is often diagnosed before diabetes.


MODY 6 (Neuro- D1) Extremely rare form of MODY. Severity of diabetes unknown as yet.
Might I have MODY?
You might have MODY if you have a strong history of diabetes in your family, and you developed diabetes before middle age, you are not overweight, and you are treated on meal planning alone, diabetes pills or on low doses of insulin (less than 0.5 units of insulin per Kg of body weight) more than 18 months after you were diagnosed with diabetes.

Research in MODY
If you live in the U.K. and think you have MODY, there is currently research into MODY going on in Birmingham and Exeter. We are currently looking for families with a child who might have MODY to look for further genes for MODY. If you want further information on this study, please contact:

Dr. John Porter BA (Hons) (Oxon) MBBS MRCPCH
Diabetes U.K. Clinical Research Fellow
Birmingham Children's Hospital
e-mail: j.porter[at]bham.ac.uk

You are a little confused about colitis. There is no such thing as "Mucosal colitis". This would be a PROPERTY of ulcerative colitis, which IS an autoimmune disease. Sometimes it is called "Mucosal Ulcerative Colitis". Here is a list of autoimmune diseases for you. Note that Lupus is considered to be an autoimmune disease, there are not different causes in this case.What

Kinds of Problems Are Caused by Autoimmunity?
Autoimmunity can affect almost any organ or body system. The exact problem one has with autoimmunity (or its diseases) depends on which tissues are targeted.

If the skin is the target, you may have skin rashes, blisters, or color changes. If it's the thyroid gland, you may be tired, gain weight, be more sensitive to cold, and have muscle aches. If it's the joints, you may have joint pain, stiffness, and loss of function.

You may know which organ or system is affected from the start. But you may not know the site of the attack. In many people, the first symptoms are fatigue, muscle aches, and low fever.

Where Does Autoimmunity Strike?
Because autoimmune diseases can affect almost any organ or system of the body, one way to group them is by the body system(s) they attack. The following is a list (not inclusive) of body systems and the autoimmune diseases that can affect them.

Blood and blood vessels

Autoimmune hemolytic anemia
Pernicious anemia
Polyarteritis nodosa
Systemic lupus erythematosus
Wegener's granulomatosis
Digestive tract (including the mouth)

Autoimmune hepatitis
Behet's disease
Crohn's disease
Primary biliary cirrhosis
Scleroderma
Ulcerative colitis
Eyes

Sjgren's syndrome
Type 1 diabetes mellitus
Uveitis
Glands

Graves' disease
Thyroiditis
Type 1 diabetes mellitus
Heart

Myocarditis
Rheumatic fever
Scleroderma
Systemic lupus erythematosus
Joints

Ankylosing spondylitis
Rheumatoid arthritis
Systemic lupus erythematosus
Kidneys

Glomerulonephritis
Systemic lupus erythematosus
Type 1 diabetes mellitus
Lungs

Rheumatoid arthritis
Sarcoidosis
Scleroderma
Systemic lupus erythematosus
Muscles

Dermatomyositis
Myasthenia gravis
Polymyositis
Nerves and brain

Guillain-Barr syndrome
Multiple sclerosis
Systemic lupus erythematosus
Skin

Alopecia areata
Pemphigus/pemphigoid
Psoriasis
Scleroderma
Systemic lupus erythematosus
Vitiligo

You are probably right that mucosial colitis is not autoimmune, (I'm not familiar with it myself) but I do know that ulcerative colitis (along with Chrohn's Disease) IS believed to be caused by autoimmunity, and studies indicate that many type 1 patients have relatives with other autoimmune diseases, or they themselves have more than one. Most notably, there is a statistically significant correlation between type 1 diabetes and celiac disease. The most common way of "treating" autoimmune diseases is, at this time, to treat the symptoms of the disease, not the disease itself. There are over 80 reported autoimmune diseases on record. For more details, there are several good resources including the NIH and several nonprofit organizations which have accurate and reliable info. on the subject:

Autoimmunity: Questions and Answers About Autoimmunity
Publication from the National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS/National Institutes of Health (NIH Publication No. 02-4858)
http://www.niams.nih.gov/hi/topics/a...toimmunity.pdf

National Institutes of Health, The Autoimmune Diseases Coordinating Committee report to Congress http://www.niaid.nih.gov/dait/pdf/ADCC_Final.pdf

American Autoimmune Related Diseases Association
http://www.aarda.org/

__________________
Type 1 since September 1976 (dx'd age 7). Now age 37. Blog: http://sstrumello.blogspot.com/. Yahoo Group: http://health.groups.yahoo.com/groups/DiabetesPortal. NYC Advocacy Website:
http://www.stopnyca1ctracking.org.

when I was 2 i was dxd as having it. colitis runs in the family.
the intestinal lining is shed. Its in th ibs family of disorders. it can either be inherited, aquired or developed.