Thread: Neuropathy
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Old 11.14.2006, 04:26 AM
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Quote:
Originally Posted by jimmys devoted View Post
Neuropathy.
You may have heard about it but not really ahve a clue as to what it is.

Neuropathy is the degredation of the melin sheath( fat sheath) of the nerves that insulate it from surrounding tissues.

Actually, this describes Multiple Sclerosis, an autoimmune disease.

This is caused by Ketosis or Ketones.

Neuropathy is NOT caused by ketones. Healthy people can develop "ketosis" when fasting, they never get neuropathy. Also, many Type 2's can never develop ketones like Type 1's can, and they still develop nerve damage.

It is caused by AGE cross linking of glycogen with proteins, caused by high glucose levels, AND the high oxidative stress found in diabetics. AGE levels correlate with A1c levels, indirectly. The higher the A1c, the more AGE damage you are accumulating. In Type 1 diabetes, there is also evidence to suggest that a complete lack of c-peptide and even autoimmune mechanisms is to blame in some cases.


The nerves are bare like a chewed wire and the electrical impuses flow over into the surrounding tissue.
This creates afeeling of heat, pins and needles, pain and RLS.

I don't understand what you mean. Nerve impulses can only be conducted along nerves and nerve tissue. These feelings are due to changes in sorbitol levels within the nerves, and/or lack of oxygen and blood supply.
Neuropathy can be ocntrolled, but it never really goes away.


Treatmenst vary.
How do or those you know cope with neuropathy?
Benfotiamine (synthetic fat soluble B1) is known to help, as can any anti-oxidant. Omega 3's EFA's and Alpha Lipoic Acid can also be used to reduce inflammation.

Here is a link dicussing more of the biochemical pathways of neuropathy...

http://pioneer.netserv.chula.ac.th/~asithipo/MAPK-DN.pdf#search='etiology%20of%20diabetic%20neuropat hy'
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